Amphetamine is known to inhibit monoamine oxidase, whereas the flexibility of amphetamine and its metabolites to inhibit a variety of P450 isozymes and also other enzymes hasn't been adequately elucidated. In vitro experiments with human microsomes indicate insignificant inhibition of CYP2D6 by amphetamine and minor inhibition of CYP1A2, 2D6, and 3